MAIN OPPORTUNISTIC ENTERIC PROTOZOA RELATED TO AIDS: CRYPTOSPORIDIUM PARVUM, ISOSPORA BELLI, CYCLOSPORA CAYETANENSIS AND MICROSPORIDIA

Authors

  • Gabriel Veloso Cunha Universidade Católica de Brasília
  • Lucas Benfica Paz Universidade Católica de Brasília
  • Ettore Mendes Azenha Universidade Católica de Brasília
  • Rosalvo Streit Junior Universidade Católica de Brasília
  • Douglas Araújo dos Santos Albernaz Universidade Católica de Brasília

DOI:

https://doi.org/10.13037/ras.vol16n55.4723

Keywords:

HIV, AIDS, opportunistic parasites, emerging parasites

Abstract

Introduction: It is estimated that there are more than 33 million AIDS cases worldwide. In this sense, some parasitoses has become important public health problems, by taking advantage of the vulnerability due to this clinical condition. Objective: To list and discuss the main opportunistic parasitosis found in individuals with AIDS, exploring the life cycle of their agents, pathogenesis, clinical manifestations, prevention, diagnostic and treatment. Methods: Searches have been conducted, without temporal limits, at the virtual databases Public Medline (PubMed), Scientific Electronic Library Online (SciELO) and Biblioteca Virtual em Saúde (BVS) in order to select case reports, epidemiological bulletins, experimental papers and pertinent literature reviews. Results: Among the main opportunistic parasites found in patients with AIDS there are microsporidia and coccidia such as: Isospora belli, Cyclospora sp. and Cryptosporidium sp., for which a systematic literature review has been performed in this article. Conclusions: It is evident the necessity of developing more efficient treatments with less adverse effects, besides a better diagnostic accuracy by health professionals, and environmental tracking by competent institutions.

Downloads

Download data is not yet available.

Author Biographies

Gabriel Veloso Cunha, Universidade Católica de Brasília

Lucas Benfica Paz, Universidade Católica de Brasília

Ettore Mendes Azenha, Universidade Católica de Brasília

Rosalvo Streit Junior, Universidade Católica de Brasília

Douglas Araújo dos Santos Albernaz, Universidade Católica de Brasília

References

Lewis DA. Review of the book A history of the African AIDS epidemic. Sex Transm Infect. 2006;82(3):266.

Biswas MHA. AIDS epidemic worldwide and the millennium development strategies: a light for lives. HIV AIDS Rev. 2012;11(4):87-94.

Lawn SD, Török ME, Wood R. Optimum time to start antiretroviral therapy during HIV-associated opportunistic infections. Curr Opin Infect Dis. 2011;24(1):34-42.

Smith E. Dawning answers: how the HIV/AIDS epidemic has helped to strengthen public health. J Epidemiol Community Health. 2004;58(4):355.

Bonnet F, Chêne G. Evolving epidemiology of malignancies in HIV. Curr Opin Oncol. 2008;20(5):534-40.

Feinstein MJ, Bogorodskaya M, Bloomfield GS, Vendanthan R, Siedner MJ, Kwan GF, et al. Cardiovascular complications of HIV in endemic countries. Curr Cardiol Rep. 2016;18(11):113.

Bitew H, Andargie G, Tadesse A, Belete A, Fekadu W, Mekonen T. Suicidal ideation, attempt, and determining factors among HIV/AIDS patients, Ethiopia. Depress Res Treat. 2016;2016:8913160.

Caceres NA, Vieira MMC, Vieira IF, Monteleone VF, Moreira Neto LJ, Bonafe S. Opportunistic infections in AIDS patients. Arch Med. 2015;7(5):1-17.

Sandhu A, Samra AK. Opportunistic infections and disease implications in HIV/AIDS. Int J Pharm Sci Invent. 2013;2(5):47-54.

Benamrouz S, Conseil V, Creusy C, Calderon E, Dei-Cas E, Certad G. Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa). Parasite. 2012;19(2):101-15.

O’Hara SP, Chen XM. The cell biology of cryptosporidium infection. Microbes Infect. 2011;13(8-9):721-30.

Ferreira MS, Borges AS. Some aspects of protozoan infections in immunocompromised patients: a review. Mem Inst Oswaldo Cruz. 2002;97(4):443-57.

Widmer G, Sullivan S. Genomics and population biology of Cryptosporidium species. Parasite Immunol. 2012;34(2-3):61-71.

Shirley DA, Moonah SN, Kotloff KL. Burden of disease from cryptosporidiosis. Curr Opin Infect Dis. 2012;25(5):555-63.

Ryan U, Hijjawi N. New developments in Cryptosporidium research. Int J Parasitol. 2015;45(6):367-73.

Bouzid M, Hunter PR, Chalmers RM, Tyler KM. Cryptosporidium pathogenicity and virulence. Clin Microbiol Rev. 2013;26(1):115-34.

Assis DC, Resende DV, Cabrine-Santos M, Correia D, Oliveira-Silva MB. Prevalence and genetic characterization of Cryptosporidium spp. and Cystoisospora belli in HIV-infected patients. Rev Inst Med Trop Sao Paulo. 2013;55(3):149-54.

Sponseller JK, Griffiths JK, Tzipori S. The evolution of respiratory Cryptosporidiosis: evidence for transmission by inhalation. Clin Microbiol Rev. 2014;27(3):575-86.

Patricia Neira O, Elizabeth Barthel M, Gonzalo Wilson L, Nelson Muñoz S. Infección por Isospora belli en pacientes coninfección por VIH. Presentación de dos casos y revisión de la literatura. Rev Chil Infect. 2010;27(3):219-27.

Lindsay DS, Dubey JP, Blagburn BL. Biology of Isospora spp. from humans, nonhuman primates, and domestic animals. Clin Microbiol Rev. 1997;10(1):19-34.

Frenkel JK, Silva MB, Saldanha JC, Silva-Vergara ML, Correia D, Barata CH, et al. Extraintestinal finding of Isospora belli unizoic cysts in a patient with AIDS: case report. Rev Soc Bras Med Trop. 2003;36(3):409-12.

Yazar S, Yalcln S, Sahin Í. Human cyclosporiosis in Turkey. World J Gastroenterol. 2004;10(12):1844-47.

Mezzari A, Antunes HBB, Wiebbelling AMP. Cyclospora cayetanensis, um novo protozoário a ser pesquisado. Rev Ass Med Brasil. 1999;45(4):347-8.

Ortega YR, Sanchez R. Update on Cyclospora cayetanensis, a food-borne and waterborne parasite. Clin Microbiol Rev. 2010;23(1):218-34.

Chawla R, Ichhpujani RL. Enteric spore-forming opportunistic parasites in HIV/AIDS. Trop Parasitol. 2011;1(1):15-9.

Arora DR, Arora B. AIDS – associated parasitic diarrhoea. Indian J Med Microbiol. 2009;27(3):185-90.

Weitz Vattuone JC, Carolina Weitz R, Marilena Canales R, Ruy Moya R. Infección por Cyclospora cayetanensis: revisión a propósito de tres casos de diarrea del viajero. Rev Chil Infectol. 2009;26(6):549-54.

Field AS, Milner Junior DA. Intestinal microsporidiosis. Clin Lab Med. 2015;35(2):445-59.

Ghosh K, Weiss LM. T cell response and persistence of the microsporidia. FEMS Microbiol Rev. 2012;36(3):748-60.

Didier ES, Stovall ME, Green LC, Brindley PJ, Sestak K, Didier PJ. Epidemiology of microsporidiosis: sources and modes of transmission. Vet Parasitol. 2004;126(1-2):145-66.

Saharia KK, Koup RA. T cell susceptibility to HIV influences outcome of opportunistic infections. Cell. 2013;155(3):505-14.

Didier ES, Weiss LM. Microsporidiosis: not just in AIDS patients. Curr Opin Infect Dis. 2011;24(5):490-5.

Izquierdo F, Castro Hermida JA, Fenoy S, Mezo M, González-Warleta M, Aguila C. Detection of microsporidia in drinking water, wastewater and recreational rivers. Water Res. 2011;45(16):4837-43.

Franzen C. Microsporidia: how can they invade other cells? Trends Parasitol. 2004;20(6):275-9.

Yazar S, Koru Ö, Hamamci B, Çetinkaya Ü, Karaman Ü, Kuk S. Mikrosporidialar ve Mikrosporidiyozis. Turkiye Parazitol Derg. 2013;37:123-34.

Ramanan P, Pritt BS. Extraintestinal microsporidiosis. J Clin Microbiol. 2014;52(11):3839-44.

Anane S, Attouchi H. Microsporidiosis: epidemiology, clinical data and therapy. Gastroenterol Clin Biol. 2010;34(8-9):450-64.

Alkatan HM, Al-Zaaidi S, Athmanathan S. Microsporidial keratitis: literature review and report of 2 cases in a tertiary eye care center. Saudi J Ophthalmol. 2012;26(2):199-203.

Decraene V, Lebbad M, Botero-Kleiven S, Gustavsson A-M, Löfdahl M. First reported foodborne outbreak associated with microsporidia, Sweden, October 2009. Epidemiol Infect. 2012;140(3):519-27.

Rivero-Rodríguez Z, Hernández A, Bracho Á, Salazar S, Villalobos R. Prevalencia de microsporidios intestinales y otros enteroparásitos en pacientes con VIH positivo de Maracaibo, Venezuela. Biomed. 2013;33(4):538-45.

Rigo CR, Franco RMB. Comparison between the modified Ziehl-Neelsen and Acid-Fast-Trichrome methods for fecal screening of Cryptosporidium parvum and Isospora belli. Rev Soc Bras Med Trop. 2002;35(3):209-14.

Checkley W, White Junior AC, Jaganath D, Arrowood MJ, Chalmers RM, Chen XM, et al. A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium. Lancet Infect Dis. 2015;15(1):85-94.

Chako CZ, Tyler JW, Schultz LG, Chiguma L, Beernsten BT. Cryptosporidiosis in people: it’s not just about the cows. J Vet Intern Med. 2010;24(1):37-43.

Murphy K, Travers P, Walport M. Imunobiologia de Janeway. Porto Alegre: Artmed, 2010.

Lodi S, Del Amo J, Moreno S, Bucher HC, Furrer H, Logan R, et al. Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries. AIDS. 2014;28(16):2461-73.

Sancak B, Akyon Y, Ergüven S. Cyclospora infection in five immunocompetent patients in a Turkish university hospital. J Med Microbiol. 2006;55(Pt 4):459-62.

Chacín-Bonilla L. Cyclospora cayetanensis as a global health problem. Epidemiol. 2012;2(3):e110.

desVignes-Kendrick M, Reynolds K, Lee T, Gaul L, Klein K, Irvin K, et al. Notes from the field: outbreaks of Cyclosporiasis – United States, June-August 2013. Centers for Disease Control and Prevention Morb. Mortal. Wkly. Rep (MMWR). 2013;62(43):862.

Published

2018-04-13

Issue

Section

ARTIGOS DE REVISÃO