Implicações Biológicas de Monômeros de Uso Odontológico

Autores

  • Guilherme Anziliero Arossi Universidade Luterana do Brasil- Campus Torres RS.

DOI:

https://doi.org/10.13037/rbcs.vol11n35.1842

Palavras-chave:

potencial tóxico, resinas compostas, adesivos dentinários.

Resumo

Este trabalho investigou na literatura o potencial tóxico de todos os monômeros (TEGDMA, HEMA, UDMA e BisGMA) e derivados monoméricos (resinas compostas e adesivos dentinários) utilizados na composição de materiais resinosos de aplicação odontológica. Esses materiais vêm sendo usado amplamente como polímeros compostos capazes de restabelecer função e estética em reabilitações orais. Todas as evidências - embasadas em numerosas pesquisas - apontam para o risco potencial associado aos adesivos e as resinas compostas, para a saúde dos pacientes e dos profissionais da área odontológica. No entanto, a significância clínica destes achados deve ser interpretada de uma forma mais ampla, associando formas de minimizar o impacto tóxico dos monômeros na saúde bucal humana, tais como utilizando  materiais ionoméricos como forma de proteger o tecido pulpar,  fiscalização e conscientização da necessidade de uma polimerização adequada de tais materiais, e utilização de restaurações cerâmicas, que utilizam produtos monoméricos apenas em sua cimentação, diminuindo a biodisponibilidade monomérica para o meio bucal e pulpar.

Downloads

Não há dados estatísticos.

Biografia do Autor

Guilherme Anziliero Arossi, Universidade Luterana do Brasil- Campus Torres RS.

Mestre em Odontologia,  Doutor em Genética e Toxicologia Aplicada,  Professor Adjunto do Curso de Odontologia ULBRA Torres.

Referências

1. Roulet JF, Degrange M. Adhesion: the silent revolution in dentistry. Chicago: Quintessence Books; 2000.

2. Busato ALS, Barbosa AN, Porto CLA, Reston EG, Saad JRC, Reichert LA et al. Dentística – Novos princípios restauradores. São Paulo: Editora Artes Médicas Ltda., 2004.

3. Formolo E, Demarco FF, Barbosa NA, Braghini M, Rodrigues JRS. Prevalência de restaurações de amálgama ou resina composta em

dentes posteriores: estudo preliminar. JBC j. bras. clin. odontol. integr.. 2003;7:120-124.

4. Menezes JA. Ditadura da beleza. Epistem. somat. 2006;3:265-267.

5. Centola ALB, Nascimento TN, Giraldi KCFM. Reanatomização: procedimento utilizado para reabilitação da estética – relatos de casos

clínicos. Jornal Brasileiro de Clinica & Estética em Odontologia. 2000;4:42-45.

6. França FM, Worschech CC, Paulillo LA, Martins LR, Lovadino JR. Fracture resistance of premolar teeth restored with different filling

techniques. J Contemp Dent Pract. 2005;6:62-69.

7. Soares PV, Santos-Filho PC, Martins LR, Soares CJ. Influence of restorative technique on the biomechanical behavior of endodontically treated maxillary premolars. Part I: fracture resistance and fracture mode. J Prosthet Dent. 2008;99:30-37.

8. Colman HL, Entwistle B, Meskin L. Changing patient needs and their impact on clinical education. J Dent Educ. 1985;49:636-39.

9. Spencer P, Bohaty B, Haynes JI, Iwersen AE, Sabates C. Change in dental treatment needs in an urban pediatric population, 1977 to 1987. ASDC J Dent Child. 1989;56:463-66.

10. Widdop FT. Caring for the dentate elderly. Int Dent J. 1989;39:85-94.

11. Arossi GA. Avaliação de microdureza superficial de resinas compostas submetidas a diferentes métodos de polimerização complementar. [Dissertação]. Canoas: Universidade Luterana do Brasil; 2004.

12. Ferracane JL. Correlation between hardness and degree of conversion during the setting reaction of unfilled dental restorative resins. Dent. mater. 1985;1:11-14.

13. Kildal KK, Ruyter IE. How different curing methods affect the degree of conversion of resinbased inlay/onlay materials. Acta Odontol Scand. 1993;52:315-22.

14. Park SH, Lee CS. The difference in degree of conversion between light-cured and additional heat-cured composites. Oper. Dent. 1996;21:213-17.

15. Bagis YH, Rueggeberg FA. Mass loss in urethane/TEGDMA and BisGMA/TEGDMA based resin composites during post cure heating. Dent. mater. 1997;13:377-80.

16. Gerzina TM, Hume WR. Diffusion of monomers from bonding resin-resin composite combination through dentin in vitro. J. Dent. 1996;24:125-28.

17. Ortengren U, Wellendorf H, Karlsson S, Ruyter IE. Water sorption and solubility of dental composites and identification of monomers

released in an aqueous environment. J. oral rehabil. 2001;28:1106-15.

18. Yap AU, Lee HK, Sabapathy R. Release of methacrylic acid from dental composites. Dent. mater. 2000;16:172-79.

19. Geurtsen W. Biocompatibility of nonamalgam dental filling materials. Crit Rev Oral Biol Med. 2000;11:333-55.

20. Leggat PA, Kedjarune U. Toxicity of methyl methacrylate in dentistry. Int Dent J. 2003;53:126-31.

21. Al-Hiyasat AS, Darmani H, Elbetieha AM. Effects of bisphenol A on adult male mouse fertility. European Journal of Oral Science. 2002;110:163-67.

22. Schwengberg S, Bohlen H, Kleinsasser N, Kehe K, Seiss M, Walther UI et al. Vitro embryotoxicity assessment with dental restorative materials. J Dent. 2005;33:49-55.

23. Darmani H, Al-Hiyasat AS. The resin monomer triethylene glycol dimethacrylate exhibits reproductive toxicity in male mice. Reprod. fertil. dev. 2005;17:401-406.

24. Darmani H, Al-Hiyasat AS. The effects of BISGMA and TEG-DMA on female mouse fertility. Dent. mater. 2006;22:353-358.

25. Engelmann J, Leyhausen G, Leibfritz D, Geurtsen W. Metabolic effects of dental resin components in vitro detected by NMR spectroscopy. J. dent. res. 2001;80:869-75.

26. Walther UI, Walther SC, Liebl B, Reichl FX, Kehe K, Nilius M et al. Cytotoxicity of ingredients of various dental materials and related compounds in L2- and A549 cells. J Biomed Mater Res. 2002;63:643-49.

27. Moharamzadeh K, Van Noort R, Brook IM, Scutt AM. Cytotoxicity of resin monomers on human gingival fibroblasts and HaCaT keratinocytes. Dent. mater. 2007;23:40-44.

28. Thonemann B, Schmalz G, Hiller KA, Schweikl H. Responses of L929 mouse fibroblasts, primary and immortalized bovine dental papilladerived cell lines to dental resin components. Dent. mater. 2002;18:318-23.

29. Janke V, Von Neuhoff N, Schlegelberger B, Leyhausen G, Geurtsen W. TEGDMA causes apoptosis in primary human gingival fibroblasts. J. dent. res. 2003;82:814-18.

30. Becher R, Kopperud HM, Al RH, Samuelsen JT, Morisbak E, Dahlman HJ et al. Pattern of cell death after in vitro exposure to GDMA, TEGDMA e HEMA and two compomers extracts. Dent. mater. 2005;22:630-40.

31. Li N, Miao X, Takakuwa M, Sato K, Sato A. Effect of dental material HEMA monomer on human dental pulp cells. Artif Cells Blood Substit Immobil Biotechnol. 1999;27:85-90.

32. Gioka C, Bourauel C, Hiskia A, Kletsas D, Eliades T, Eliades G. Light-cured or chemically cured orthodontic adhesive resins? A selection based on the degree of cure, monomer leaching, and cytotoxicity. Am J Orthod Dentofacial Orthop. 2005;127:413-19.

33. Vahid A, Hadjati J, Kermanshah H, Ghabraei S. Effects of cured dentin bonding materials on human monocyte viability. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:619-21.

34. Costa CA, Hebling J, Hanks CT. Current status of pulp capping with dentin adhesive systems: a review. Dent mater. 2000;16:188-97.

35. Schmalz G, Schuster U, Koch A, Schweikl H. Cytotoxicity of low pH dentin-bonding agents in a dentin barrier test in vitro. J Endod. 2002;28:188- 92.

36. Al-Hiyasat AS, Darmani H, Milhem MM. Cytotoxicity evaluation of dental resin composites and their flowable derivatives. Clinical Oral Investigation. 2005;9:21-5.

37. Darmani H, Al-Hiyasat AS, Milhem MM. Cytotoxicity of dental composites and their leached components. Quintessence Int. 2007;38:789-95.

38. Pfeiffer E, Rosenberg B, Deuschel S, Metzler M. Interference with microtubules and induction of micronuclei in vitro by various bisphenols. Mutat Res. 1997;390:21-31.

39. Lehmann L, Metzler M. Bisphenol A and its methylated congeners inhibit growth and interfere with microtubules in human fibroblasts in vitro. Chem Biol Interact. 2004;147:273-85.

40. Schweikl H, Schmalz G, Spruss T. The induction of micronuclei in vitro by unpolymerized resin monomers. J. dent. res. 2001;80:1615-20.

41. Schweikl H, Schmalz G, Rackebrandt, K. The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutat Res. 1998;415:119-30.

42. Kleinsasser NH, Wallner BC, Harreus UA, Kleinjung T, Folwaczny M, Hickel R et al. Genotoxicity and cytotoxicity of dental materials in

human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. J. dent. 2004;32:229-34.

43. Schweikl H, Schmalz G. Triethylene glycol dimethacrylate induces large deletions in the hprt gene of V79 cells. Mutat Res. 1999;438:71–8.

44. Schweikl H, Spagnuolo G, Schmalz G. Genetic and cellular toxicology of dental resin monomers. J. dent. res. 2006;85:870-7.

45. Stanislawski L, Lefeuvre M, Bourd K, SoheiliMajd E, Goldberg M, Perianin A. TEGDMA-induced toxicity in human fibroblasts is associated with early and drastic glutathione depletion with subsequent production of oxygen reactive species. J Biomed

Mater Res. 2003;66:476-82.

46. Chang HH, Guo MK, Kasten FH, Chang MC Huang GF, Wang YL et al. Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA. Biomaterials. 2005;26:745-53.

47. Lee DH, Lim BS, Lee YK, Ahn SJ, Yang HC. Involvement of oxidative stress in mutagenicity and apoptosis caused by dental resin monomers in cell cultures. Dent. mater. 2006;22:1086-92.

48. Schweikl H, Hartmann A, Hiller KA, Spagnuolo G, Bolay C, Brockhoff G et al. Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent. mater. 2007;23:688-95.

49. Walther UI, Siagian II, Walther SC, Reichl FX, Hickel R. Antioxidative vitamins decrease cytotoxicity of HEMA and TEGDMA in cultured cell lines. Arch. oral. biol. 2004;49:125-31.

50. Arossi GA, Dihl RR, Lehmann M, Reguly ML, Andrade HH. Genetic toxicology of dental composite resin extracts in somatic cells in vivo. Basic Clin Pharmacol Toxicol. 2010;107(1):625-9.

51. Arossi GA, Lehmann M, Dihl RR, Reguly ML, Andrade HHR. Induced DNA Damage by Dental Resin Monomers in Somatic Cells. Basic Clin Pharmacol Toxicol. 2010;106:124-129.

52. Arossi GA, Dihl RR, Lehmann M, Cunha KS, Reguly ML, Andrade HHR. In vivo genotoxicity of dental bonding agents. Mutagenesis. 2008;24:169-72.

53. Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science. 1995;268:225-32.

54. ST. John MA, Xu T. Understanding human cancer in a fly? Am J Hum Genet. 1997;61:1006-10.

55. Andrade HHR, Reguly ML, Lehmann M. Wing somatic mutation and recombination test. In: Henderson, D.S. (Ed). Drosophila Cytogenetics Protocols. New Jersey: Humana Press, 2004; 389-412.

56. Kleinsasser NH, Schmid K, Sassen AW, Harreus UA, Staudenmaier R, Folwaczny M et al. Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials. 2006;27:1762-70.

57. Geurtsen W, Leyhausen G. Chemicalbiological interactions of the resin monomer triethyleneglycol-dimethacrylate (TEGDMA). J Dent

Res. 2001;80:2046-2050.

58. Eckhardt A, Gerstmayr N, Hiller K, Bolay C, Waha C, Spagnuolo G et al. TEGDMA-induced oxidative DNA damage and activation of ATM and MAP kinases. Biomaterials, 2009;30:2006-14.

59. Besaratinia A, Pfeifer GP. DNA adduction and mutagenic properties of acrylamide. Mutat Res. 2005;580:31-40.

60. Lee RP, Parkinson A, Forkert PG. Isozymeselective metabolism of ethyl carbamate by cytochrome P450 (CYP2E1) and carboxylesterase (hydrolase A) enzymes in murine liver microsomes. Drug Metab Dispos. 1998;26:60-5.

61. Schweikl H, Schmalz G. The induction of micronuclei in V79 cells by the root canal filling material AH Plus. Biomaterials. 2000;21:939-44.

62. Schweikl H, Schmalz G, Federlin M. Mutagenicity of the root canal sealer AH Plus in the Ames test. Clinical Oral Investigation. 1998;2:125-9.

63. Miletic I, Jukic S, Anic I, Zeljezic D, GarajVrhovac V, Osmak, M. Examination of cytotoxicity and mutagenicity of AH26 and AH Plus sealers. Int Endod J. 2003;36:330-5.

64. Bakopoulou A, Mourelatos D, Tsiftsoglou AS, Giassin NP, Mioglou E, Garefis P. Genotoxic and cytotoxic effects of different types of dental cement on normal cultured human lymphocytes. Mutat Res. 2009;672:103-12.

65. Schweikl H, Hiller KA, Bolay C, Kreissl M, Kreismann W, Nusser A et al. Cytotoxic and mutagenic effects of dental composite materials.

Biomaterials. 2005;26:1713-19.

66. Schweikl H, Schmalz G, Weinmann W. The induction of gene mutations and micronuclei by oxiranes and siloranes in mammalian cells in vitro. J Dent Res. 2004;83:17-21.

67. Demirci M, Hiller KA, Bosl C, Galler K., Schmalz G, Schweikl H. The induction of oxidative stress, cytotoxicity, and genotoxicity by dental adhesives. Dent. mater. 2008;24:362-71.

68. Bakopoulou A, Mourelatos D, Tsiftsoglou AS, Mioglou E, Garefis P. Sister-chromatid exchange, chromosomal aberrations and delays in cell-cycle

Downloads

Publicado

2013-05-14

Edição

Seção

ARTIGOS DE REVISÃO

Artigos Semelhantes

<< < 9 10 

Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.